Overnight Brisket Marinade

Brisket marinade

The Spruce

Prep: 15 mins
Cook: 5 mins
Total: 20 mins
Serving: 1 serving
Yield: 2 1/2 cups
Nutrition Facts (per serving)
1306 Calories
109g Fat
19g Carbs
2g Protein
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Nutrition Facts
Servings: 1
Amount per serving
Calories 1306
% Daily Value*
Total Fat 109g 140%
Saturated Fat 15g 75%
Cholesterol 0mg 0%
Sodium 2231mg 97%
Total Carbohydrate 19g 7%
Dietary Fiber 3g 10%
Total Sugars 4g
Protein 2g
Vitamin C 9mg 45%
Calcium 71mg 5%
Iron 3mg 18%
Potassium 649mg 14%
*The % Daily Value (DV) tells you how much a nutrient in a food serving contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.
(Nutrition information is calculated using an ingredient database and should be considered an estimate.)

A marinade can make a tremendous difference when you're cooking meat. It serves so many purposes. It's a fantastic way to add a lot of flavor while also tenderizing tougher cuts of meat and adding moisture, too.

In the case of a brisket, a marinade will offer all of that and more. This marinade offers a pungent hit of both horseradish and mustard, red wine, olive oil, lemon juice, wine vinegar, salt, and onion and garlic powders. It calls for cayenne, but you can use less or skip it if your crowd isn't into heat.

This marinade is great because you can either make it way ahead of time, such as a week in advance, then keep it in the fridge, or you can use it to marinate a brisket, keep it in the fridge overnight, and cook it the next day. Whether you are smoking or grilling a brisket, this marinade will add a lot of flavor and help keep the meat tender.


  • 1 1/2 cups red wine

  • 1/2 cup olive oil

  • 1 1/2 tablespoons mustard

  • 1 1/2 tablespoons lemon juice

  • 1 tablespoonred wine vinegar

  • 1 tablespoon horseradish

  • 1 1/2 teaspoons kosher salt

  • 1 teaspoon cayenne pepper, use less or omit if preferred

  • 1 teaspoon onion powder

  • 1 teaspoon garlic powder

Steps to Make It

  1. Gather the ingredients.

    Ingredients for brisket marinade
    The Spruce
  2. Whisk ingredients together in a small bowl.

    Whisk brisket marinade ingredients
    The Spruce
  3. Pour the marinade over brisket and let it marinate overnight in the refrigerator, turning occasionally.

    Pour marinade over brisket
    The Spruce
  4. Remove brisket from marinade and boil the remaining marinade for 5 minutes to use as a mop.


  • If you want to make the marinade ahead of time, it will keep for up to a week in the refrigerator.
  • Use the remaining marinade to make what's a called a mop, Boil the leftover marinade for at least five minutes to destroy any bacteria. Use this thin sauce to brush over or "mop" on top of the meat for extra flavor during the cooking process, whether it's smoking, grilling, or braising.

How to Use Overnight Brisket Marinade

You can use this over a brisket, but it's also great as a marinade on other cuts of beef and pork.

Here are a few ideas:

Smoked Mini-Brisket

Slow Cooker Brisket With Caramelized Onions

Instant Pot Pulled Pork

Crock Pot Pulled Pork Sandwiches