Top 11 Main Dish Macaroni and Cheese Combinations

Macaroni and Cheese With Chicken Sausage
Diana Rattray

Looking to take your classic, homemade macaroni and cheese to the next level? This collection of delectable macaroni and cheese variations will not disappoint. These simple twists on America's favorite side transform the dish to a hearty main course. Here's your chance to explore some new flavor combinations and choose from a variety of protein and vegetable additions. Perfect one variation or try them all—one cheesy bite at a time.

  • 01 of 11

    Sloppy Joe Macaroni and Cheese

    Sloppy Joe Macaroni and Cheese
    Diana Rattray

    This genius combination is sure to please the kids. The sloppy Joe filling goes perfectly with the deliciously gooey macaroni and cheese. It's a pairing of two favorites that can't be beat.

    This dish can also be made with ground turkey.

  • 02 of 11

    Macaroni and Cheese With Andouille Sausage

    Mac and Cheese

    JeffKearney/Getty Images 

    Spicy Cajun-style andouille sausage and Cajun seasonings give this scrumptious macaroni and cheese its incredible smoky flavor and a bit of heat. Make the recipe with macaroni or other pasta shapes. 

    If you don't have access to good smoked andouille sausage, try this recipe with another variety of smoked sausage. Chorizo or a tasty turkey or chicken sausage would be excellent as well. Add a little cayenne pepper to the dish for more heat.

  • 03 of 11

    Macaroni and Cheese with Pulled Pork

    Macaroni and Cheese With Pulled Pork
    Diana Rattray

    This macaroni and cheese with pulled pork consists of two comfort foods in one dish.

    You can use homemade leftover pulled pork or a purchased tub of pulled pork. Add a little extra barbecue sauce to the pulled pork before baking.

    Serve this dish with slaw and biscuits or dinner rolls. Be sure to save the recipe because you'll be asked to make it again.

  • 04 of 11

    Macaroni and Cheese With Bacon

    Bacon mac and cheese

    The Spruce

    Cooked smoky bacon jazzes up this mac and cheese bake. The bacon crumbles are sprinkled over the top of the macaroni and cheese along with buttery breadcrumbs. This casserole can be served as a main dish or side dish. Add a salad or sliced tomatoes for a memorable meal.

    Continue to 5 of 11 below.
  • 05 of 11

    Chicken Pasta Casserole With Cheddar Cheese and Bacon

    Chicken Pasta Casserole With Cheddar and Bacon
    Diana Rattray

    This savory casserole offers a fabulous combination of flavors, from the cheddar and American cheeses to the smoky bacon, chicken, and peas. Use elbow macaroni or a mini penne pasta in this dish.

  • 06 of 11

    Taco Cheeseburger Macaroni

    Taco Macaroni and Cheese with Ground Beef
    Diana Rattray

    This main dish mac and cheese combines taco seasonings with cheeseburger flavors. It's easy and delicious, and your family will request it again and again.

    The cheddar cheese soup mixed with shredded cheddar make it especially creamy, and the preparation is quick and easy.

  • 07 of 11

    Macaroni and Cheese With Chicken Sausage

    Macaroni and Cheese With Chicken Sausage
    Diana Rattray

    There is spinach, fontina cheese, and roasted garlic chicken sausage (Trader Joe's) in this dish, but feel free to use your favorite flavored chicken sausage in the dish. The macaroni and cheese is super creamy and gets a lot of flavor from your sausage of choice.

  • 08 of 11

    Baked Macaroni and Cheese With Ham

    Baked Macaroni and Cheese With Ham

    Diana Rattray

    You can't go wrong with this hearty macaroni and cheese with chopped ham and green onions. The casserole is made with plenty of cheese in the sauce, and cheese is sprinkled over the top. It's finished with a delicious buttered bread crumb topping.

    Continue to 9 of 11 below.
  • 09 of 11

    Chicken and Cheddar Casserole With Macaroni

    Chicken, Cheddar, and Bacon Casserole

    Diana Rattray

    This hearty macaroni and cheese casserole is baked with an unexpected topping of French fried onion rings. It's an all-in-one meal your family will love. Use frozen peas, carrots, or mixed vegetables in this dish.

  • 10 of 11

    Macaroni and Cheese With Italian Sausage

    Macaroni and Cheese With Sausage
    Diana Rattray

    This macaroni and cheese is hearty and yummy with browned spicy or Italian sausage, bell peppers, and sliced grape tomatoes. The dish is prepared with a mixture of cheddar and American cheese, but any good mixture of melting cheese can be substituted.

  • 11 of 11

    Tex-Mex Macaroni and Cheese

    Tex-Mex Style Macaroni and Cheese
    Diana Rattray

    The Tex-Mex flavors of ground beef, bell pepper, tomatoes, and corn come together in this delicious dish. The skillet dish is made with a prepared macaroni and cheese dinner, making it super easy and convenient for a busy family.