Meatloaf Sandwich Recipe

Meatloaf Sandwich

 Kristina Vanni

Prep: 20 mins
Cook: 60 mins
Total: 80 mins
Servings: 4 sandwiches
Nutrition Facts (per serving)
692 Calories
32g Fat
52g Carbs
47g Protein
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Nutrition Facts
Servings: 4
Amount per serving
Calories 692
% Daily Value*
Total Fat 32g 41%
Saturated Fat 13g 66%
Cholesterol 173mg 58%
Sodium 1935mg 84%
Total Carbohydrate 52g 19%
Dietary Fiber 4g 14%
Total Sugars 15g
Protein 47g
Vitamin C 12mg 61%
Calcium 415mg 32%
Iron 7mg 38%
Potassium 928mg 20%
*The % Daily Value (DV) tells you how much a nutrient in a food serving contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.
(Nutrition information is calculated using an ingredient database and should be considered an estimate.)

The only thing better than an old-fashioned family style meatloaf for dinner? Getting to enjoy the leftovers in a sandwich the next day! When making a meatloaf sandwich, you can certainly use your favorite recipe passed down from your grandma. Most of the time these recipes use flavorful 80/20 ground beef. You can also use a supermarket pre-packaged "meatloaf mix" with a combination of ground beef, pork, and veal. For a lighter version, ground turkey or ground chicken are also an option. No matter what recipe you begin with, the next day it is all about how you assemble the sandwich.

For a meatloaf sandwich, it's best to turn to ingredients that are traditional and classic. Start with old school fluffy white sandwich bread, it just tastes best in this case. Then top with crisp lettuce for crunch and color. It's nice to bump up the flavor of the sliced meatloaf with a bit of extra ketchup before layering on a slice of your favorite cheddar cheese. Of course, a sandwich like this should be served with a pickle on the side. Since meatloaf sandwiches are most frequently enjoyed as leftovers the next day, they are often enjoyed cold. However, if you prefer your meatloaf sandwich warm, simply microwave the meatloaf slices before assembling the sandwich.


For the Meatloaf:

  • 1 cup milk

  • 1 large egg

  • 1/2 cup saltine cracker crumbs

  • 1/2 cup coarsely chopped onion

  • 1/4 cup coarsely chopped green pepper

  • 1 tablespoon prepared horseradish

  • 1 tablespoon ketchup

  • 1 1/2 teaspoons salt

  • 1 teaspoon sugar

  • 1/4 teaspoon freshly ground black pepper

  • 1 pound 80/20 ground beef

For the Sandwich:

  • 8 slices white sandwich bread

  • 4 large lettuce leaves

  • 4 slices sharp cheddar cheese

  • Ketchup, to taste

  • Pickle spears, for serving

Steps to Make It

  1. Gather the ingredients. Preheat oven to 350 degrees F. Lightly coat an 8-inch by 4-inch loaf pan with cooking spray.

    Meatloaf Sandwich
     Kristina Vanni
  2. In a large bowl, whisk together the milk and egg.

    Meatloaf Sandwich
     Kristina Vanni
  3. Add the cracker crumbs, onion, green pepper, horseradish, ketchup, , salt, sugar, and black pepper. Stir to combine.

    Meatloaf Sandwich
    Kristina Vanni 
  4. Add the ground beef and mix by hand to combine. Do not over work.

    Meatloaf Sandwich
     Kristina Vanni
  5. Spoon into the prepared loaf pan. Bake in the preheated 350 degree oven for 55 to 60 minutes or until cooked through.

    Meatloaf Sandwich
     Kristina Vanni
  6. Remove from the oven and cool on a wire rack for about 5 minutes. 

    Meatloaf Sandwich
     Kristina Vanni
  7. Remove the meatloaf from the pan and cut it into eight even slices.

    Meatloaf Sandwich
     Kristina Vanni
  8. To assemble a sandwich, place a lettuce leaf on the bottom piece of bread. Top with 2 slices of meatloaf to cover the surface of the bread. Top with a slice of cheese and a squeeze of ketchup. Place the second piece of bread on top to complete the sandwich.

    Meatloaf Sandwich
     Kristina Vanni
  9. Enjoy! Serve hot or cold with crisp dill pickle spears on the side.

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